High-level resistance to gentamicin in clinical isolates of Streptococcus (Enterococcus) faecium
نویسندگان
چکیده
منابع مشابه
High-level resistance to gentamicin in clinical isolates of Streptococcus (Enterococcus) faecium.
During a 14-month period beginning in July 1986, three distinct clinical isolates of Streptococcus (Enterococcus) faecium demonstrating high-level resistance (MIC, greater than 2,000 micrograms/ml) to gentamicin, kanamycin, tobramycin, and streptomycin were recovered from individual patients at one institution. Combinations of ampicillin with any of these agents failed to show bactericidal syne...
متن کاملHeterogeneity of plasmids determining high-level resistance to gentamicin in clinical isolates of Streptococcus faecalis.
Between November 1981 and October 1984, 48 of 3,458 clinical isolates of Streptococcus faecalis at the University of Michigan Hospital showed high-level (greater than 2,000 micrograms/ml) resistance to gentamicin, as well as to all other clinically available aminoglycosides. Thirteen percent of clinical isolates in the University of Michigan Hospital currently demonstrate this level of resistan...
متن کاملhigh level resistance of enterococcus faecium and e. faecalis isolates from municipal sewage treatment plants to gentamicin
background: enterococci are members of the normal gut flora and released into the environment via sewage outlets, where they can survive for long times. infections with high-level gentamicin resistant (hlgr) enterococci are emerging worldwide. hlgr enterococci have developed a resistance to most antibiotics commonly used for enterococcal infections therefore; treatment of infections caused b...
متن کاملComparison of high-level gentamicin-resistant Enterococcus faecium isolates from different continents.
Eight clinical isolates of Enterococcus faecium highly resistant to gentamicin (MIC, > 1,000 mg/liter) from patients in six hospitals on three continents were investigated for evidence of spread of either a clone of high-level gentamicin-resistant (HLGR) E. faecium or wide dissemination of a gentamicin resistance (Gmr) plasmid. A combination of ribotypes, plasmid profiles, and extended antimicr...
متن کاملHigh-level penicillin resistance and penicillin-gentamicin synergy in Enterococcus faecium.
Thirty-seven Enterococcus faecium strains with different levels of penicillin susceptibility were studied in time-kill experiments with a fixed concentration (5 micrograms/ml) of gentamicin combined with different penicillin concentrations (6 to 600 micrograms/ml). Synergy was defined as a relative decrease in counts of greater than 2 log10 CFU per milliliter after 24 h of incubation when the c...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1988
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.32.10.1528